|
KMID : 0604520150410030269
|
|
Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 3 p.269 ~ p.277
|
|
|
A Study of the Antioxidant Activities and Whitening Activities of Areca semen Extracts as Cosmetic Ingredient
|
|
Kang Hee-Cheol
Cha Mi-Yeon
Kim Jae-Young
|
|
|
Abstract
|
|
|
|
Herbal plant extracts are good resources to find functional compounds for cosmetic ingredient. In this study, the extract of Areca semen (A. semen) was studied for melanogenesis inhibition and antioxidant activity. The results showed that ethyl acetate fraction of A. semen contained phenolic contents, 301.35 ± 0.88 μg/mg, and exhibited potent antioxidant activity with IC50 value of 1.02 ± 0.07 μg/mL. Further, FRAP value exhibited potent antioxidant activity with 9.07 ± 0.36 mM. Disk diffusion assay was performed for antibacterial activity. Ethyl acetate fraction of A. semen showed antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) at 80 μg/mL, whereas it showed no significant antibacterial activity against Escherichia coli (E. coli). The results of cell viability indicated that ethyl acetate fraction did not show cytotoxicity to B16/F1 cells at 80 μg/mL and showed significant cytotoxicity at 100 μg/mL of concentration and showed inhibition of melanin synthesis inhibitory, 29.78 ± 0.31% at 80 μg/mL. Furthermore, mRNA expressions of tyrosinase and MITF were decreased after treatment with ethyl acetate fraction in a dose-dependent manner. As a result, the ethyl acetate fraction of A. semen could be considered as potential as whitening agents.
|
|
|
KEYWORD
|
|
|
antioxidant, whitening, Areca semen, cosmetics, antibacterial
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|